BM607

BM607: Medical Devices and Equipment
Course plan for Jan – Apr 2020

Total lectures: 42
Total labs: 12
Total credits: 4
Maximum student intake: 25
Priority of student enrollment:   BME M.Tech., PhD any branch, M.Tech. any branch (Except BME), B.Tech.

Lab: Weightage (20)
Project: Starts after the second week of January.  Students shall be divided into groups of four. Each group needs to choose a project from the list and work on making a prototype till the end of the course. Materials and equipment shall be supplied from the Medical Devices Lab (MDL). Mentoring by research scholars of MDL and few clinicians shall be available.
Literature survey of project: Weightage (5)
Project paper: Weightage (5)
Project proof of concept: Weightage (20) 

Mid-sem: Weightage (20)
End-Sem: Weightage (30)

Hospital tour and an industry tour may be organized.
Invited lectures: 4-5

23-24 Jan: Sessions by Mr. Gautham Pasupuleti on following:

Day 1 :  Medical Device Innovations from Idea to Market (Perspective from students, early stage startups) – Overview Involving Design thinking Process for Development of Medical Devices , Problem Identification, Need Statement refinement, Design and Development of Prototype Process, Proof of Concept to Minimum Viable Product, Bench studies, Usability Studies, Clinical Trials and Go to Market Strategies. 

Day 2 :  Case Studies on Medical Device Innovations, Business Models for Medical Device Companies, Grant Writing, Filing IP and Regulatory Pathway Strategies. 

Jan 29: Planned visit of Parmar Hospital

Feb 15: Tour of Tynor Orthotics, Mohali

Suggested books: 

1. Medical Instrumentation, John G. Webster
2. Medical Instruments and Devices, Steven Schreiner, et. al

Lectures List (Tentative):

Lecture 1: Introduction, Generalized Medical Instrumentation System, Basic biostatistics
Lecture 2: Biostatistics continued, Static Characteristics, Accuracy, precision, resolution, reproducibility, Static sensitivity, Zero Drift, Sensitivity drift, Linearity, Input range
Lecture 3: Generalized dynamic characteristics, Zero order instrument, first order instrument, second order instrument, Time delay, Design process of medical instruments.
Lecture 4: Regulation of medical devices. (Probable support from Mr. Ameel)
Lecture 5: Sensors, Displacement measurement using potentiometers, Strain gauges, Wheatstone bridge.
Lecture 6: LVDT, Capacitive sensors
Lecture 7: Piezoelectric sensors.
Lecture 8: Thermocouples, RTD, Thermistors, Radiation thermometry, Fibre optic temp sensors.
Lecture 9: Radiation sources, Radiation sensors, fibre optics
Lecture 10: Opamp circuits refresher, Biopotential amplifiers, Isolation amplifier, Surge protection
Lecture 11-13: Origin of biopotentials, Electromyogram, Nerve conduction velocity, ECG, EEG, Electroretinogram, Electro-oculogram, Magnetoencephalogram.
Lecture 14: Biopotential electrodes
Lecture 15: Frequently encountered artefacts and interferences
Lecture 16: Blood pressure measurement methods.
Lecture 18: Heart sounds, stethoscope and tonometry
Lecture 19: Measurement of flow and volume of the blood
Lecture 20: Measurement of flow and volume of the blood
Lecture 21: Measurement of Gas flow, lung volume and respiratory plethysmography.
Lecture 22: Measurement of respiratory mechanics, Measurement of Gas concentration
Lecture 23: Chemical biosensors, blood gas Acid-base physiology
Lecture 24: Blood glucose sensors, Electronic noses
Lecture 25: Clinical laboratory instrumentation
Lecture 26: Clinical laboratory instrumentation
Lecture 27: Ultrasound imaging
Lecture 28: Ultrasound imaging
Lecture 29: Ventilators
Lecture 30: Neonatal technologies (Probable assistance from Dr. Kamal)
Lecture 31: Electrosurgical Instruments (Probable help from Dr. Parmar)
Lecture 32: Electrical Safety
Lecture 33: Laser basics
Lecture 34: Mobile App development
Lecture 35: Ophthalmic instruments and assessment of vision.
Lecture 36: Prosthetics and orthotics
Lecture 37: Hearing rehabilitation.

 

Lab List (Tentative):

1. Design a muscle stimulator circuit and perform the same by using the iworks.
2. Record of Hospital visit.(Parmar Hospital).
3. Benchside to bedside two day lectures, write a lab record what they learnt in it.
4. 3D design on solid works and 3D printing.
5. Acoustic and thermal simulation on Comsol.
6. Verasonics Ultrasound programming experiment.
7. Biosensing experiment of Glucose detection.
8. Android App development for a heart sound recorder
9. Eye and Ear instruments demonstration and use.
10. Cardiac pump flow demonstration and pressure measurement.
11. Phantom design process.

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Lecture and lab list of Jan – Apr 2019

Lecture 1: Introduction to the course.
Lecture 2: Bio-potential Amplifiers
Lecture 3: Differential amplifier and Instrumentation amplifier with CMRR calculations.
Lecture 4-5: Invited lecture on “3D Modelling and printing technologies for medical device applications and restorative solutions” by Dr. Prashant Jindal and Mamta Juneja, UIET.
Lab 1: Introduction to DAQ in LabVIEW using USB-6001.
Lecture 6: Isolation amplifier, Surge protection, Stethoscope (History, principle, frequency response), Standing wave in open and closed tube (theory and demonstration)
Lecture 7: Student research paper presentations.
Lecture 8: Pulse-Oximetry
Lab 2: Making a GUI based audio recorder, player and spectral analyzer in Matlab. Addendum: Operating the pulse-oximeter.
Lecture 9: ECG review and cardiac Arrhythmias.
Lecture 10: Student paper presentations.
Lecture 11: Invited lecture on “Fundamentals of cryosurgery” by Krishna Ramajayam, University of North Carolina.
Lab 3: Evaluation of grip strength from EMG signals and Matlab analysis. Addendum: Observing through the otoscope.
Lecture 12: Invited lecture on “Medical device regulations and standards” by Mohammad Ameel, Senior Consultant, Healthcare Technologies, WHO CC for Priority Medical Devices & Health Technology Policy, National Health Systems Resource Centre.
Lab 4: Visit to Dev’s Dental Clinic and Parmar Hospital, Rupnagar
Lecture 13: Invited lecture on “Ethics, clinical trials and informed consent process while validating medical devices.” by Dr. Ajay Prakash, Assistant Professor of Pharmacology, PGIMER
Lecture 14: Measurement of cardiac output.
Lecture 15: Measurement of ejection fraction and spirometry.
Lecture 16: Student presentations
Lab 5: Stimulation of radial nerve.
Lecture 17: HITLAB summit on digital health.
Lecture 18: Electrosurgery
Lecture 19: Assessment of Vision
Lecture 20: Student presentations
Lab 6: COMSOL simulation of stress and bending of a cantilever beam

Mid-Sem

CBME MedTech Workshop

Lecture 21: Discussion of Mid-Sem Questions
Lecture 22: Bio-electrical Impedance Measurement
Lecture 23: Impedance plethysmography, Impedance cardiography, Impedance tomography
Lecture 24: Fundamentals of sound propagation.
Lecture 25: Fundamentals of ultrasound
Lab 7: 3D printing of 1:2 ratio gears with axle
Lecture 26: Arterial stiffness measurement using ultrasound. Student presentation on ARFI
Lecture 27:  Physiology based signal processing algorithm design (Examples from ARTSENS). Envelope detection, method of prominent peak detection, identifying and tracking moving structures. Differentiating carotid artery and and jugular vein. Student presentation on perfusion imaging.
Lecture 28:  Understanding Jugular venous pulse (JVP), Physiology based modelling of data (example from arterial diameter measurement). Understanding arterial blood gas analysis. Student presentation on a bio-inspired biopsy device.
Lab 8: Data analysis of A-mode ultrasound obtained from carotid arteries to estimate the arterial stiffness.
Lecture 29:  Blood gas analysis with examples. Intubation procedure.  Bag valve mask device operation. Mechanical ventilation basics. Student presentation on measurement of ICP.
Lecture 30: Weaning from ventilator, ABG considerations while ventilating, Manometer basics, Bernoulli’s equations, flow measurement with venturimeter. Student presentation on acoustic estimation of pulmonary edema.
Lecture 31: Principles of blood pressure measurement using mercury sphygmomanometer. Student presentation on wearable headband for epileptic seizure detection.
Lab 9: Flow control of a peristaltic pump using pulse width modulation.
Lecture 32: Quiz
Lecture 33: Oscillometric blood pressure measurement, Properties of Lasers, Student presentation on salivary blood glucose measurement.
Lecture 34: Theory of lasers, Student presentation on VR based laproscopic training system.
Lab 10: Driving a stepper motor with serial commands.
Lecture 35: Evaluation of student presentations and conclusion